• Muhammad Arif Department of Physics, FMIPA, University of Indonesia, Depok 16424, Indonesia
  • Warsito Purwo Taruno CTech Labs Edwar Technology, Tangerang 15320, Indonesia
  • Septelia Inawati Wanandi Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia
  • Anto Sulaksono Department of Physics, FMIPA, University of Indonesia, Depok 16424, Indonesia
Keywords: cancer cell, lesion, electric field, dielectrophoresis force, dielectric constant, TTFields, ECCT


Researchers have used electric fields as a new therapeutic strategy to treat cancer for the past 15 years. Tumor Treating Fields (TTFields) is an alternating electric field-based cancer therapy approved by the US FDA to treat glioblastoma multiforme (GBM). ECCT (Electro-Capacitive Cancer therapy), a DC charged-discharged electric field (EF) cancer therapy, also shows a performance inhibiting cell proliferation. ECCT affects the cancer lesions to cause simultaneous death of the cancer cell and detached off of the surrounding tissue. The author hypothesizes that the EF produces an electric force that is not homogeneous throughout the tumor mass and generates a strong dielectrophoresis force. The force affects microtubules polymerization during mitosis and causes mitotic arrest. To examine this hypothesis, we performed a numerical simulation of the EF distribution and calculated the force acting on the tumor mass generated by the EF. We analyzed DC electric field exposure on a cancer lesion using a single lesion 2D circular model, calculated the EF intensity on the lesion using the Finite Element Method, and the dielectrophoresis force distribution to quantify the treatment efficacy. The results showed that the distribution of EF intensity was not homogeneous at the lesion-medium boundary and homogeneous within the lesion. The EF intensity is highly dependent on the dielectric constant of the medium and the applied voltage difference that may affect the effectiveness of the treatment. Variations in lesion diameter had no significant effect on the EF intensity distribution and, hence the effectiveness of the therapy. It is considered that EF exposure by ECCT generated strong force on the lesion-medium boundary that could cause detachment of the tumor mass from the surrounding tissue.


E. D. Kirson et al., “Disruption of Cancer Cell Replication by Alternating Electric Fields,” Cancer research, vol. 64, no. 9, pp. 3288-3295, 2004.

C. Wenger et al., “Modeling Tumor Treating Fields (TTFields) application in single cells during metaphase and telophase,” IEEE, pp. 6892-6895, 2015.

C. Wenger et al., “A Review on Tumor-Treating Fields (TTFields): Clinical Implications Inferred from Computational Modeling,” IEEE R Reviews in Biomedical Engineering, vol. 11, pp. 195-207, 2018.

R. Stupp et al., “NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomized phase III trial of a novel treatment modality,” European Journal of Cancer, vol. 48, no. 14, pp. 2192-2202, 2012.

A. A. Rehman, K. B. Elmore and T. A. Mattei, “The effects of alternating electric fields in glioblastoma: current evidence on therapeutic mechanisms and clinical outcomes,” W Neurosurgical Focus, vol. 38, no. 3, p. E14, 2015.

R. Pratiwi et al., “CCL2 and IL18 expressions may associate with the anti-proliferative effect of noncontact electro capacitive cancer therapy in vivo,” F1000Research, vol. 8, p. 1770, 2019.

F. Alamsyah et al., “Cytotoxic T cells response with decreased CD4/CD8 ratio during mammary tumors inhibition in rats induced by non-contact electric fields,” F1000Research, vol. 10, pp. 35, 2021.

S. A. Mujib, F. Alamsyah and W. P. Taruno, “Cell Death and Induced p53 Expression in Oral Cancer, HeLa, and Bone Marrow Mesenchyme Cells under the Exposure to Noncontact Electric Fields,” Integrative Medicine International, vol. 4, no. 3-4, pp. 161-170, 2017.

S. Grimnes and O. G. Martinsen, “Bioimpedance and Bioelectricity Basics,” Biomedical Engineering, 2000.

J. Zhang, K. Chen and Z. H. Fan, “Circulating tumor cells: Isolation and analysis,” 1st ed. Nashville, TN: John Wiley & Sons, pp. 1-31, 2016.

J. A. Tuszynski et al., “An overview of sub-cellular mechanisms involved in the action of TTFields,” International Journal of Environmental Research and Public Health, vol. 13, no. 11, pp. 1-23, 2016.

X. Li et al., “A Theoretical Analysis of the Effects of Tumor-Treating Electric Fields on Single Cells,” Bioelectromagnetics, vol. 41, no. 6, pp. 438-446, 2020.

T. Kotnik and D. Miklavčič, “Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields,” Bioelectromagnetics, vol. 21, no. 5, pp. 385-394, 2000.

J. S. Marshall and S. Li, “Adhesive Particle Flows,” 2014.

P. R. C. Gascoyne et al., “Membrane changes accompanying the induced differentiation of Friend murine erythroleukemia cells studied by dielectrophoresis,” BBA - Biomembr, vol. 1149, no. 1, pp. 119-126, 1993.

R. Buchner, G. T. Hefter and P. M. May, “Dielectric relaxation of aqueous NaCl solutions,” The Journal of Physical Chemistry A, vol. 103, no. 1, pp. 8-9, 1999.

“Dielectric Properties,”, [Online]. Available:, [Accessed: 31-Jul-2021].

X. Li, F. Yang, and B. Rubinsky, “A Theoretical Study on the Biophysical Mechanisms by Which Tumor Treating Fields Affect Tumor Cells during Mitosis,” IEEE Transactions on Biomedical Engineering, vol. 67, no. 9, pp. 2594-2602, 2020.

How to Cite
Arif, M., Taruno, W. P., Wanandi, S. I., & Sulaksono, A. (2021). NUMERICAL ANALYSIS OF ELECTRIC FORCE DISTRIBUTION ON TUMOR MASS IN DC ELECTRIC FIELD EXPOSURE. Spektra: Jurnal Fisika Dan Aplikasinya, 6(2), 89 - 100.