BIOFILTER MANUFACTURE OF AZADIRACHTA INDICA LEAF POWDER AND ITS EFFECTIVENESS IN CAPTURING FREE RADICALS OF CIGARETTE SMOKE

Agus Mulyono

doi:10.21009/SPEKTRA.072.01

Authors

Agus Mulyono Physics Department, Universitas Islam Negeri Maulana Malik Ibrahim, Indonesia

DOI:

https://doi.org/10.21009/SPEKTRA.072.01

Keywords:

biofilter, cigarette smoke, Azadirachta Indica, free radicals

Abstract

Free radicals from cigarette smoke are a dangerous part that must be found to counteract. This research aims to make a composite biofilter made from Azadirachta Indica to ward off/capture free radicals from cigarette smoke. This biofilter is made with Azadirachta Indica leaf powder added to polyethylene glycol as the matrix. The biofilter was then seen for its physical characteristics; the density and porosity were tested using SEM. Furthermore, a biofilter membrane is used to filter cigarette smoke. Cigarette smoke that passes through the biofilter is then analyzed using ESR for its free radical content. The results showed that the biofilter made from Azadirachta Indica leaves could absorb several types of suspected free radicals in cigarette smoke. Biofilters using PEG as a matrix with a mass of 0.9 and 1gr were the most effective in absorbing the suspected types of free radicals. SEM test showed an average pore size of 2-3 µm for a mass of 1gr with PEG as the matrix.

References

[1] G. S. Becker, M. Grossman and K. M. Murphy, “An empirical analysis of cigarette addiction,” Am. Econ. Rev, vol. 84, no. 3, pp. 396-418, 1994, doi: 10.7312/GROS17812-025/MACHINEREADABLECITATION/RIS.
[2] J. W. McEvoy et al., “Cigarette Smoking and Cardiovascular Events: Role of Inflammation and Infclinical Atherosclerosis from the Multiethnic Study of Atherosclerosis,” Arterioscler. Thromb. Vasc. Biol, vol. 35, no. 3, pp. 700-709, 2015, doi: 10.1161/ATVBAHA.114.304562.
[3] F. F. K. Fitria et al., “Merokok dan Oksidasi DNA,” Sains Med, vol. 5, no. 2, pp. 113-120, 2013, [Online], Available: http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/352.
[4] K. Khotimah, “THE CORRELATION BETWEEN THE DEGREE OF SMOKING BY BRINKMAN INDEX AND THE LUNG VITAL CAPACITY,” Apr. 2016, Accessed: Nov. 14, 2021, [Online], Available: http://ners.unair.ac.id.
[5] S. M. Reilly et al., “Brand variation in oxidant production in mainstream cigarette smoke: Carbonyls and free radicals,” Food Chem. Toxicol, vol. 106, pp. 147-154, Aug. 2017, doi: 10.1016/J.FCT.2017.05.035.
[6] N. L. Benowitz, “Nicotine Addiction,” vol. 362, no. 24, pp. 2295-2303, Jun. 2010, http://dx.doi.org/10.1056/NEJMra0809890, doi: 10.1056/NEJMRA0809890.
[7] A. A. Lopes et al., “Antioxidant action of propolis on mouse lungs exposed to short-term cigarette smoke,” Bioorg. Med. Chem, vol. 21, no. 24, pp. 7570-7577, Dec. 2013, doi: 10.1016/J.BMC.2013.10.044.
[8] A. Santo, H. Zhu, and Y. R. Li, “Free Radicals: From Health to Disease,” React. Oxyg. Species, October 2016, doi: 10.20455/ros.2016.847.
[9] D. Ezz-Din et al., “Physiological and histological impact of Azadirachta indica (neem) leaves extract in a rat model of cisplatin-induced hepato and nephrotoxicity,” J. Med. Plant Res, vol. 5, no. 23, pp. 5499-5506, 2011.
[10] A. Khafid et al., “Buletin Anatomi dan Fisiologi,” vol. 6, no. 1, 2021.
[11] A. K. Ghimeray et al., “Antioxidant activity and quantitative estimation of azadirachtin and nimbin in Azadirachta Indica A. Juss grown in foothills of Nepal,” African J. Biotechnol, vol. 8, no. 13, pp. 3084-3091, 2009, doi: 10.4314/ajb.v8i13.60994.
[12] A. I. Airaodion et al., “Comparative Assessment of Phytochemical Content and Antioxidant Potential of Azadirachta indica and Parquetina nigrescens Leaves,” Asian Plant Res. J, vol. 2, pp. 1-14, 2019, doi: 10.9734/aprj/2019/v2i330045.
[13] A. S. Li’aini, I. P. A. H. Wibawa and I. N. Lugrayasa, “Karakterisasi Aktivitas Antioksidan Ekstrak Daun Mimba (Azadirachta Indica A. Juss) dari Desa Jagaraga, Kecamatan Sawan, Kabupaten Buleleng, Bali,” Bul. Plasma Nutfah, vol. 27, no. 1, p. 51, 2021, doi: 10.21082/blpn.v27n1.2021.p51-56.
[14] S. Simon, B. Yunianta and M. Rifa’i, “Aktivitas Antioksidan Fraksi Metanol Ekstrak Daun Mimba (Azardirachta Indica Juss),” Seniati, vol. 3, no. 2085-4218, pp. 59-63, 2018.
[15] G. Pandey, K. Verma and M. Singh, “Evaluation of phytochemical, antibacterial and free radical scavenging properties of Azadirachta indica (neem) leaves,” Int. J. Pharm. Pharm. Sci, vol. 6, no. 2, pp. 444-447, 2014.
[16] F. Rinaldi et al., “Neem oil nanoemulsions: characterisation and antioxidant activity,” vol. 32, no. 1, pp. 1265-1273, Jan. 2017, https://doi.org/10.1080/14756366.2017.1378190, doi: 10.1080/14756366.2017.1378190.
[17] Supriyanto et al., “Uji fitokimia dan aktivitas antioksidan ekstrak daun mimba (Azaradiracta indica Juss),” Prosiding SNATIF, pp. 523-529, 2017.
[18] A. A. S. A. Sukmaningsih et al., “The potency of java plum (Syzgium cumini) fruit extract as free radical scavenging in cigarette smoke,” AIP Conf. Proc, vol. 2155, September, 2019, doi: 10.1063/1.5125519.
[19] M. Delaval et al., “Novel instrument to generate representative e-cigarette vapors for physicochemical particle characterization and in-vitro toxicity,” J. Aerosol Sci, vol. 129, pp. 40-52, Mar. 2019, doi: 10.1016/J.JAEROSCI.2018.11.011.
[20] Nurmayanti, Vivi and Erna Hastuti, “Karakterisasi sifat fisis membran polimer matrik komposit (PMC) dari karbon aktif tempurung kelapa untuk adsorbsi logam berat pada minyak goreng bekas,” Jurnal Neutrino: Jurnal Fisika dan Aplikasinya, 2014.