Advancing X-Ray Medical Imaging through Compton Scattering Technologies: A Systematic Review of Technological Developments and AI-Based Image Reconstruction
DOI:
https://doi.org/10.21009/SPEKTRA.102.05Keywords:
compton scattering, x-ray imaging, compton tomography, inverse compton source, image reconstruction, machine learning, medical diagnosticsAbstract
Compton scattering has emerged as a promising advancement in X-ray medical imaging, offering enhanced spatial resolution and diagnostic precision compared to conventional techniques. This study employs a Systematic Literature Review (SLR) to evaluate the contributions of Compton scattering technologies in improving imaging performance. Forty peer-reviewed articles were selected from six major databases including Google Scholar, Scopus, PubMed, Web of Science, ScienceDirect, and arXiv based on predefined inclusion criteria. The review identifies three main technological approaches which are Compton cameras, inverse Compton X-ray sources, and Compton scattering tomography. Recent innovations in image reconstruction, particularly using deep learning and convolutional neural networks, have significantly improved image quality, reduced noise, and enhanced computational efficiency. These findings underscore Compton scattering’s clinical potential, especially in soft tissue visualization and early lesion detection. This paper provides a detailed overview of current progress and strategic pathways in the development of Compton based imaging systems towards their clinical application.
References
S. Gallardo, J. Ródenas, and G. Verdú, “Monte Carlo simulation of the Compton scattering technique applied to characterize diagnostic x‐ray spectra,” Med. Phys., vol. 31, no. 7, pp. 2082–2090, 2004, doi: 10.1118/1.1759827.
M. Bech et al., “Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-rays,” J. Synchrotron Radiat., vol. 16, no. 1, pp. 43–47, 2009, doi: 10.1107/S090904950803464X.
G. Harding and B. Schreiber, “Coherent X-ray scatter imaging and its applications in biomedical science and industry,” Radiat. Phys. Chem., vol. 56, no. 1–2, pp. 229–245, 1999, doi: 10.1016/S0969-806X(99)00283-2.
J. Giersch and J. Durst, “Monte Carlo simulations in X-ray imaging,” Nucl. Instrum. Methods Phys. Res. A, vol. 591, no. 1, pp. 300–305, 2008, doi: 10.1016/j.nima.2008.03.078.
K. Maeda, M. Matsumoto, and A. Taniguchi, “Compton‐scattering measurement of diagnostic x‐ray spectrum using high‐resolution Schottky CdTe detector,” Med. Phys., vol. 32, no. 6, pp. 1542–1547, 2005, doi: 10.1118/1.1921647.
S. S. Hsieh and K. Taguchi, “Spectral information content of Compton scattering events in silicon photon counting detectors,” Med. Phys., vol. 51, no. 4, pp. 2386–2397, 2024, doi: 10.1002/mp.16990.
S. Aldawood et al., “Development of a Compton camera for prompt-gamma medical imaging,” Radiat. Phys. Chem., vol. 140, pp. 190–197, 2017, doi: 10.1016/j.radphyschem.2017.01.024.
S. M. Kim and J. S. Lee, “A comprehensive review on Compton camera image reconstruction: From principles to AI innovations,” Biomed. Eng. Lett., vol. 14, no. 6, pp. 1175–1193, 2024, doi: 10.1007/s13534-024-00418-8.
A. Omata et al., “Performance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging,” Sci. Rep., vol. 10, 13976, 2020, doi: 10.1038/s41598-020-71019-5.
H. Ding, “Compact inverse Compton scattering sources to characterize and map radionuclides,” Nat. Rev. Earth Environ., vol. 5, no. 3, p. 163, 2024, doi: 10.1038/s43017-024-00522-4.
H. G. Rinderknecht et al., “Electron-beam-based Compton scattering x-ray source for probing high-energy-density physics,” Phys. Rev. Accel. Beams, vol. 27, no. 3, 034701, 2024, doi: 10.1103/PhysRevAccelBeams.27.034701.
A. Döpp, K. Ta Phuoc, and I. A. Andriyash, “All-optical Compton scattering at shallow interaction angles,” J. Plasma Phys., vol. 89, no. 5, 965890501, 2023, doi: 10.1017/S0022377823000909.
Z. Chi, Y. Du, W. Huang, and C. Tang, “High-Efficient Compton Scattering Computed Tomography Based on a Thomson Scattering X-Ray Source,” in Emerging Radiation Detection: Technology and Applications, Cham: Springer, 2024, pp. 165–178, doi: 10.1007/978-3-031-63897-8_10.
C. Tarpau, J. Cebeiro, M. K. Nguyen, G. Rollet, and L. Dumas, “On the design of a CST system and its extension to a bi-imaging modality,” arXiv preprint, arXiv:2007.02750, 2020.
N. Tsuji, Y. Tsuji, Y. Uchimoto, H. Imai, and Y. Sakurai, “Compton scattering imaging of liquid water in porous carbon-based materials,” Appl. Sci., vol. 11, no. 9, 3851, 2021, doi: 10.3390/app11093851.
J. W. Webber and W. R. B. Lionheart, “Three dimensional Compton scattering tomography,” Inverse Probl., vol. 34, no. 8, 084001, 2018, doi: 10.1088/1361-6420/aac51e.
G. Redler et al., “Compton scatter imaging: A promising modality for image guidance in lung stereotactic body radiation therapy,” Med. Phys., vol. 45, no. 3, pp. 1233–1240, 2018, doi: 10.1002/mp.12755.
E. A. Ryan et al., “The use of Compton scattering to differentiate between classifications of normal and diseased breast tissue,” Phys. Med. Biol., vol. 50, no. 22, pp. 5263–5275, 2005, doi: 10.1088/0031-9155/50/22/010.
M. Frandes, B. Timar, and D. Lungeanu, “Image reconstruction techniques for Compton scattering based imaging: an overview [Compton based image reconstruction approaches],” Curr. Med. Imaging Rev., vol. 12, no. 2, pp. 95–105, 2016, doi: 10.2174/1573405612666160128233916.
J. Webber, E. T. Quinto, and E. L. Miller, “A joint reconstruction and lambda tomography regularization technique for energy-resolved X-ray imaging,” arXiv preprint, arXiv:2002.05356, 2020.
A. Ben-Yehuda et al., “High-resolution computed tomography with scattered X-ray radiation and a single pixel detector,” Commun. Eng., vol. 3, no. 1, 39, 2024, doi: 10.1038/s44172-024-00184-6.
Y. Huang et al., “Experimental and numerical studies on kV scattered x-ray imaging for real-time image guidance in radiation therapy,” Phys. Med. Biol., vol. 66, no. 4, 045022, 2021, doi: 10.1088/1361-6560/abd66c.
Y. Xia, Z. Chen, L. Zhang, Y. Xing, and H. Gao, “ComptoNet: An End-to-End Deep Learning Framework for Scatter Estimation in Multi-Source Stationary CT,” arXiv preprint, arXiv:2501.09986, 2025.
C. L. A. Leung et al., “Correlative full field X-ray compton scattering imaging and X-ray computed tomography for in situ observation of Li ion batteries,” Mater. Today Energy, vol. 31, 101224, 2023, doi: 10.1016/j.mtener.2022.101224.
Y. Onishi and R. Ota, “Theoretical understanding of Compton scattering-based reconstruction-free anatomical imaging method,” Phys. Rev. Appl., vol. 22, no. 2, 024049, 2024, doi: 10.1103/PhysRevApplied.22.024049.
P. Niknejadi et al., “Free-electron laser inverse-Compton interaction x-ray source,” Phys. Rev. Accel. Beams, vol. 22, no. 4, 040704, 2019, doi: 10.1103/PhysRevAccelBeams.22.040704.
E. Salazar, X. Liu, and G. Arce, “X-ray Compton backscattering imaging via structured light,” Opt. Express, vol. 30, no. 9, pp. 15211–15226, 2022, doi: 10.1364/OE.456610.
Y. Ren et al., “Compton-camera-based radiopharmaceutical imaging with an attenuation-corrected LM-MLEM reconstruction strategy,” Radiat. Meas., vol. 181, 107379, 2025, doi: 10.1016/j.radmeas.2025.107379.
K. Sato et al., “Accuracy of virtual monochromatic images generated by the decomposition of photoelectric absorption and Compton scatter in dual-energy computed tomography,” Phys. Eng. Sci. Med., vol. 45, pp. 239–249, 2022, doi: 10.1007/s13246-022-01107-5.
H. Tashima and T. Yamaya, “Compton imaging for medical applications,” Radiol. Phys. Technol., vol. 15, no. 3, pp. 187–205, 2022, doi: 10.1007/s12194-022-00666-2.
E. Frame et al., “Coded aperture and Compton imaging for the development of 225Ac‐based radiopharmaceuticals,” Med. Phys., vol. 50, no. 10, pp. 6454–6468, 2023, doi: 10.1002/mp.16717.
T. Reutershan, H. H. Effarah, and C. P. J. Barty, “Bayesian optimization of laser-Compton x-ray sources for medical imaging applications,” Proc. SPIE, vol. 12463, 124633V, 2023, doi: 10.1117/12.2654377.
J. Cebeiro et al., “On a three-dimensional Compton scattering tomography system with fixed source,” Inverse Probl., vol. 37, no. 5, 054001, 2021, doi: 10.1088/1361-6420/abf0f0.
L. Kuger and G. Rigaud, “On multiple scattering in Compton scattering tomography and its impact on fan-beam CT,” arXiv preprint, arXiv:2008.06699, 2020, doi: 10.3934/ipi.2022029.
J. Webber and E. L. Miller, “Compton scattering tomography in translational geometries,” Inverse Probl., vol. 36, no. 2, 025007, 2020, doi: 10.1088/1361-6420/ab4a32.
I. Häggström, L. M. Carter, T. J. Fuchs, and A. L. Kesner, “Depth resolved pencil beam radiography using AI—a proof of principle study,” J. Instrum., vol. 17, no. 06, P06012, 2022, doi: 10.1088/1748-0221/17/06/P06012.
A. Olafsson, R. Jeraj, and S. J. Wright, “Optimization of intensity-modulated radiation therapy with biological objectives,” Phys. Med. Biol., vol. 50, no. 22, p. 5357, 2005, doi: 10.1088/0031-9155/50/22/010.
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