Tunning Surface Hydrophilicity of PVA Nanofiber Bone Scaffolds Via Amino Acid and Nanohydroxyapatite Incorporation

Authors

  • Rohul Rizki Mubaroq Hartman Department of Physics, Faculty of Mathematic and Natural Science, IPB University, Bogor, Indonesia
  • Yessie Widya Sari Department of Physics, Faculty of Mathematic and Natural Science, IPB University, Bogor, Indonesia
  • Yusril Yusuf Department of Physics, Faculty of Mathematic and Natural Science, Gadjah Mada University, Yogyakarta, Indonesia

DOI:

https://doi.org/10.21009/SPEKTRA.111.03

Keywords:

amino-acid, bone scaffold, contact angle, electrospinning, PVA, nano-hydroxyapatite, hydrophilicity modulation

Abstract

Polyvinyl alcohol (PVA) is a biodegradable and biocompatible polymer with potential use in bone tissue engineering. However, its excessively high hydrophilicity led to poor cell adhesion, limiting its suitability as a bone scaffold. This study investigates the modification of PVA nanofibers through the incorporation of negatively charged amino acids (aspartic acid, glutamic acid) and nano-hydroxyapatite (nHA) to tailor surface hydrophilicity. Electrospun nanofiber composites of Asp/PVA/nHA and Glu/PVA/nHA were fabricated with varying nHA concentrations. Higher nHA content was found to decrease hydrophilicity, whereby Asp/PVA/nHA and Glu/PVA/nHA with nHA concentration of 3.5% were within the ideal range for optimal cell adhesion and proliferation characterized by contact angle between 40o – 70o. Samples containing Asp exhibited a lower hydrophilicity compared to their respective Glu-containing counterparts, which may correlated to the difference side chain of Asp and Glu structure. Statistically significant differences (p ≤0.05) suggest that nHA and amino acids effectively modulate surface characteristics, supporting the potential of fine-tuning PVA hydrophilicity via nHA and amino incorporation for improved performance in bone tissue engineering applications.

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Published

2026-04-30

How to Cite

Hartman, R. R. M., Sari, Y. W., & Yusuf , Y. (2026). Tunning Surface Hydrophilicity of PVA Nanofiber Bone Scaffolds Via Amino Acid and Nanohydroxyapatite Incorporation: . Spektra: Jurnal Fisika Dan Aplikasinya, 11(1). https://doi.org/10.21009/SPEKTRA.111.03

Issue

Vol. 11 No. 1 (2026): SPEKTRA: Jurnal Fisika dan Aplikasinya, Volume 11 Issue 1, April 2026

Section

Articles

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Copyright (c) 2026 Rohul Rizki Mubaroq Hartman, Yessie Widya Sari, Yusril Yusuf

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