THE BONE MICROSTRUCTURE IDENTIFICATION MODEL BASED ON BACKSCATTER MODE OF ULTRASOUND
Osteoporosis is defined by a decrease in bone mass and a deterioration in bone microstructure. It is a major public health issue and a significant economic burden for both individuals and society. Thus, monitoring bone mass and structure is necessary to prevent bone fragility and osteoporosis. This study aimed to develop a prototype of quantitative ultrasound (QUS) and to evaluate the feasibility of backscatter mode for the bone assessment. Ultrasound (US) signals that propagate through the bone can be characterized by comparing the signal from both transmitter and receiver transducers. The US backscattered signal depends on the characteristic of both medium and transducer. In this study, we analyzed the attenuated signal based on the parameters: type of bone (compact and spongy), type of coupling medium (air, starch, and gel), the angle between transducers and bone (30o, 60o, and 90o), and transducer distance (0, 10, 5, 15, 20 and 25 cm). We use only 1 MHz transducer frequency. The prototype has been evaluated by Digital Oscilloscope and LabVIEW user interface to observe received signals. The results of this study showed that there was a difference in amplitude of the US signal from compact and spongy bones. The amplitude is directly proportional to acoustic impedance and inversely proportional to the distance between transducers. There is a negative correlation between bone microstructure to attenuation, and compact bones have a greater attenuation coefficient than spongy bones.
A. Rashki Kemmak et al., “Economic burden of osteoporosis in the world: A systematic review,” Med J Islam Repub Iran, vol. 34, p. 154, 2020, doi: 10.34171/mjiri.34.154.
T. A. G. Nevin Hammam, “Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa,” Int. J. Clin. Rheumatol, 2018, doi: 10.4172/1758-4272.1000177.
S. Minisola et al., “New anabolic therapies for osteoporosis,” Intern Emerg Med, vol. 12, no. 7, pp. 915-921, Oct. 2017, doi: 10.1007/s11739-017-1719-4.
E. Hernlund et al., “Osteoporosis in the European Union: medical management, epidemiology and economic burden,” A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA), Arch Osteoporos, vol. 8, p. 136, 2013, doi: 10.1007/s11657-013-0136-1.
“Laporan-Riskesdas-2018-Nasional.pdf,” Accessed: Apr. 07, 2021. [Online]. Available: https://dinkes.kalbarprov.go.id/wp-content/uploads/2019/03/Laporan-Riskesdas-2018-Nasional.pdf.
I. Akkawi and H. Zmerly, “Osteoporosis: Current Concepts,” Joints, vol. 6, no. 2, pp. 122-127, Jun. 2018, doi: 10.1055/s-0038-1660790.
C. Hartman et al., “Assessment of Osteoporosis by Quantitative Ultrasound versus Dual Energy X-Ray Absorptiometry in Children with Chronic Rheumatic Diseases,” The Journal of Rheumatology, vol. 31, no. 5, pp. 981-985, 2004.
C. M. Langton, S. B. Palmer and R. W. Porter, “The measurement of broadband ultrasound attenuation in cancellous bone,” Eng Med, vol. 13, no. 2, pp. 89-91, Apr. 1984, doi: 10.1243/emed_jour_1984_013_022_02.
C. F. Njeh, C. M. Boivin and C. M. Langton, “The role of ultrasound in the assessment of osteoporosis: a review,” Osteoporos Int, vol. 7, no. 1, pp. 7-22, 1997, doi: 10.1007/BF01623454.
D. Hans and M. A. Krieg, “Quantitative ultrasound for the detection and management of osteoporosis,” Salud pública Méx, vol. 51, pp. s25-s37, 2009, doi: 10.1590/S0036-36342009000700006.
D. Hans and S. Baim, “Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk,” J Clin Densitom, vol. 20, no. 3, pp. 322-333, Sep. 2017, doi: 10.1016/j.jocd.2017.06.018.
Y. Lei and Y. Jiping, “Design of BMD measurement system based on FPGA,” Aug. 2012, pp. 1385-1388, doi: 10.1109/ICICEE.2012.366.
M. A. A. Wahab et al., “Design of an A-mode ultrasound amplifier for bone porosity detection,” in International Symposium on Electronics and Smart Devices (ISESD), pp. 79-84, Nov. 2016, doi: 10.1109/ISESD.2016.7886696.
Umiatin et al., “Design of bone density identification method using transmission quantitative ultrasound,” AIP Conference Proceedings, vol. 2169, no. 1, p. 030012, Nov. 2019, doi: 10.1063/1.5132662.
W. Mao et al., “Ultrasound Backscatter Technique for Assessing and Monitoring Neonatal Cancellous Bone Status in Vivo,” IEEE Access, vol. 7, pp. 157417-157426, 2019, doi: 10.1109/ACCESS.2019.2949748.
B. Lashkari, L. Yang, and A. Mandelis, “The application of backscattered ultrasound and photoacoustic signals for assessment of bone collagen and mineral contents,” Quant Imaging Med Surg, vol. 5, no. 1, pp. 46-56, Feb. 2015, doi: 10.3978/j.issn.2223-4292.2014.11.11.
C. Liu et al., “The relationship between ultrasound backscatter and trabecular anisotropic microstructure in cancellous bone,” Journal of Applied Physics, vol. 115, no. 6, p. 064906, Feb. 2014, doi: 10.1063/1.4865173.
G. Iori et al., “Estimation of Cortical Bone Microstructure From Ultrasound Backscatter,” IEEE Transactions on Ultrasounds, Ferroelectrics, and Frequency Control, vol. 68, no. 4, pp. 1081-1095, Apr. 2021, doi: 10.1109/TUFFC.2020.3033050.
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